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The Water Cooler
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Who takes Testosterone suppliments
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<blockquote data-quote="scube" data-source="post: 2485507" data-attributes="member: 8221"><p>Eur J Endocrinol. 2011 Jul 13;</p><p></p><p>Authors: Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ</p><p></p><p>Objectives: Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone repla***ent therapy from their first manifestation until maximum effects are attained.</p><p></p><p>Design: Studies in PubMed on testosterone repla***ent so far providing information on time course.</p><p></p><p>Results:</p><p></p><p> Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.</p><p></p><p> Changes in erections/ejaculations may require up to 6 months.</p><p></p><p> Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.</p><p></p><p> Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.</p><p></p><p> First effects on erythropoiesis after 3 months, peaking at 9-12 months.</p><p></p><p> Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.</p><p></p><p> Effects on lipids appear after 4 weeks, maximal after 6-12 months.</p><p></p><p> Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.</p><p></p><p> Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.</p><p></p><p> Effects on inflammation occur within 3 to 12 weeks.</p><p></p><p> Effects on bone detectable after 6 months but continue at least for 3 years.</p><p></p><p></p><p></p><p>Conclusion: the time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.</p><p></p><p>PMID: 21753068 [PubMed - as supplied by publisher]</p></blockquote><p></p>
[QUOTE="scube, post: 2485507, member: 8221"] Eur J Endocrinol. 2011 Jul 13; Authors: Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ Objectives: Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone repla***ent therapy from their first manifestation until maximum effects are attained. Design: Studies in PubMed on testosterone repla***ent so far providing information on time course. Results: Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer. Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks. First effects on erythropoiesis after 3 months, peaking at 9-12 months. Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy. Effects on lipids appear after 4 weeks, maximal after 6-12 months. Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months. Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years. Effects on inflammation occur within 3 to 12 weeks. Effects on bone detectable after 6 months but continue at least for 3 years. Conclusion: the time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity. PMID: 21753068 [PubMed - as supplied by publisher] [/QUOTE]
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