Still, the best one-shot-stop of all time is a 357 magnum with a 125 gr. JHP @ 1,500 fps...
A coroner will tell you that the a bullet in the middle of the the chest - "between the nipples" WILL drop the BG, no matter what what they are hopped up on!
From FBI reports over the past 20 years, when law enforcement got away from revolvers, and went strictly to semi-automatic handguns, the mortality rate for law enforcement officers, made a drastic increase...
I watched a video of a traffic stop in GA, I think, where the perp received 5 rounds to center mass at point blank range with a .357 and ended up paralyzed on his back in the ditch... the trooper who shot him caught a .22 round in his armpit while retreating around the front of the car and bled out internally and died calling for backup. That little round went in the side around his vest and transected his aorta.
Sucks... sometimes bad luck just gets you.