I notice most of the discussion is centered around .22 LR ... but since the original question was .22 Rimfire that would include .22 WMR as well, wouldn't it? Not a lot better, I know, but Hornady's "Critical Defense" .22 WMR at least approaches their .380 version (though I know many don't think .380's adequate, either).
![www.hornady.com_assets_images_products_ammo_gel_critical_defense_compare_22wmr_380auto.jpg](https://www.okshooters.com/data/MetaMirrorCache/www.hornady.com_assets_images_products_ammo_gel_critical_defense_compare_22wmr_380auto.jpg)