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The Water Cooler
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UK nurse says little blue pill saved her from the Virus
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<blockquote data-quote="SlugSlinger" data-source="post: 3703359" data-attributes="member: 7248"><p>Viagra potentially keeps your brain functioning as well.<img class="smilie smilie--emoji" loading="lazy" alt="😂" title="Face with tears of joy :joy:" src="https://cdn.jsdelivr.net/joypixels/assets/8.0/png/unicode/64/1f602.png" data-shortname=":joy:" /></p><p></p><p><img src="https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/news/2015/05_2015/diabetes_and_dementia/1800x1200_diabetes_and_dementia.jpg" alt="www.webmd.com" class="fr-fic fr-dii fr-draggable " style="" /></p><h3><a href="https://www.webmd.com/alzheimers/news/20211206/could-viagra-help-prevent-alzheimers" target="_blank">Could Viagra Help Prevent Alzheimer's?</a></h3><p>researchers found that those taking Viagra were 69% less likely to develop Alzheimer's, when compared to non-users. And lab experiments showed that the medication seemed to target part of the underlying disease process in Alzheimer's.</p><p><img src="https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/favicon/webmd.ico" alt="www.webmd.com" class="fr-fic fr-dii fr-draggable " style="" /> <a href="http://www.webmd.com" target="_blank">www.webmd.com</a></p><p></p><p>Dec. 8, 2021 -- The erectile dysfunction medication Viagra could potentially be used as a treatment for Alzheimer’s disease, according to a new study published in the journal Nature Aging.</p><p></p><p>Patients who used the drug sildenafil, the generic name for Viagra, were 69% less likely to develop the disease than nonusers.</p><p></p><p>“Sildenafil, which has been shown to significantly improve cognition and memory in preclinical models, presented as the best drug candidate,” Feixiong Cheng, PhD, the lead study author in the Cleveland Clinic’s Genomic Medicine Institute, said in a statement.</p><p></p><p>“Notably, we found that sildenafil use reduced the likelihood of Alzheimer’s in individuals with coronary artery disease, hypertension and type 2 diabetes, all of which are comorbidities significantly associated with risk of the disease, as well as in those without,” he said.</p><p></p><p>Alzheimer’s, which is the most common form of age-related dementia, affects hundreds of millions of people worldwide. The disease is expected to affect nearly 14 million Americans by 2050. There is no approved treatment for it.</p><p></p><p>Cheng and colleagues at the Cleveland Clinic used a large gene-mapping network to analyze whether more than 1,600 FDA-approved drugs could work against Alzheimer’s. They gave higher scores to drugs that target both amyloid and tau proteins in the brain, which are two hallmarks of the disease. Sildenafil appeared at the top of the list.</p><p></p><p>Then the researchers used a database of health insurance claims for more than 7 million people in the U.S. to understand the relationship between sildenafil and Alzheimer’s disease outcomes. They compared sildenafil users to nonusers and found that those who used the drug were 69% less likely to have the neurodegenerative disease, even after 6 years of follow-up.</p><p></p><p>After that, the research team came up with a lab model that showed the sildenafil increased brain cell growth and targeted tau proteins. The lab model could indicate how the drug influences disease-related brain changes.</p><p></p><p>But Cheng cautioned against drawing strong conclusions. The study doesn’t demonstrate a causal relationship between sildenafil and Alzheimer’s disease. Researchers will need to conduct clinical trials with a placebo control to see how well the drug works.</p></blockquote><p></p>
[QUOTE="SlugSlinger, post: 3703359, member: 7248"] Viagra potentially keeps your brain functioning as well.😂 [IMG alt="www.webmd.com"]https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/article_thumbnails/news/2015/05_2015/diabetes_and_dementia/1800x1200_diabetes_and_dementia.jpg[/IMG] [HEADING=2][URL='https://www.webmd.com/alzheimers/news/20211206/could-viagra-help-prevent-alzheimers']Could Viagra Help Prevent Alzheimer's?[/URL][/HEADING] researchers found that those taking Viagra were 69% less likely to develop Alzheimer's, when compared to non-users. And lab experiments showed that the medication seemed to target part of the underlying disease process in Alzheimer's. [IMG alt="www.webmd.com"]https://img.webmd.com/dtmcms/live/webmd/consumer_assets/site_images/favicon/webmd.ico[/IMG] [URL="http://www.webmd.com"]www.webmd.com[/URL] Dec. 8, 2021 -- The erectile dysfunction medication Viagra could potentially be used as a treatment for Alzheimer’s disease, according to a new study published in the journal Nature Aging. Patients who used the drug sildenafil, the generic name for Viagra, were 69% less likely to develop the disease than nonusers. “Sildenafil, which has been shown to significantly improve cognition and memory in preclinical models, presented as the best drug candidate,” Feixiong Cheng, PhD, the lead study author in the Cleveland Clinic’s Genomic Medicine Institute, said in a statement. “Notably, we found that sildenafil use reduced the likelihood of Alzheimer’s in individuals with coronary artery disease, hypertension and type 2 diabetes, all of which are comorbidities significantly associated with risk of the disease, as well as in those without,” he said. Alzheimer’s, which is the most common form of age-related dementia, affects hundreds of millions of people worldwide. The disease is expected to affect nearly 14 million Americans by 2050. There is no approved treatment for it. Cheng and colleagues at the Cleveland Clinic used a large gene-mapping network to analyze whether more than 1,600 FDA-approved drugs could work against Alzheimer’s. They gave higher scores to drugs that target both amyloid and tau proteins in the brain, which are two hallmarks of the disease. Sildenafil appeared at the top of the list. Then the researchers used a database of health insurance claims for more than 7 million people in the U.S. to understand the relationship between sildenafil and Alzheimer’s disease outcomes. They compared sildenafil users to nonusers and found that those who used the drug were 69% less likely to have the neurodegenerative disease, even after 6 years of follow-up. After that, the research team came up with a lab model that showed the sildenafil increased brain cell growth and targeted tau proteins. The lab model could indicate how the drug influences disease-related brain changes. But Cheng cautioned against drawing strong conclusions. The study doesn’t demonstrate a causal relationship between sildenafil and Alzheimer’s disease. Researchers will need to conduct clinical trials with a placebo control to see how well the drug works. [/QUOTE]
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