Not only different calibers including, but not necessarily limited to, 22, 380, 9mm, 38, 357 mag, 357 sig, 40, 41 mag, 44 mag, 454 casull, 10mm, 45 colt, 45 acp., but a Glock 27 and 33. I know they are the same weapon, but I bought the 27 from Bud's and had it shipped to my FFL and he ordered a 33 for me without my knowledge because he could get it in the same configuration for $200 less. He is a real handy guy to have around! I don't think a person can have too many different calibers laying around because you may not be able to find ammo for the one or two you decide to keep. It is a good excuse when the wife asks anyway.