This whole thread proves my point in many threads I've posted in about reloading.
Find a powder that works for you, and run with it. You can't go wrong.
When I select a powder, I look for one that gives the greatest velocity with the minimum powder.
Doesn't make a lot of difference in pistol loading, but it makes a huge difference in rifle rounds.
Do you chronograph your loads or go by published reloading data?