I carry a 45, but it really depends on what you consider comfortable and what you feel confident in using. Most people prefer a 380 or a 9mm for carry from my experience of selling firearms.
well I am a .45 man myself , but as far as "pocket" carry and I mean inside the pants pocket? There arent many .45's that will be that comfortable inside the pants pocket , I think the .380 is the best , I also put the Makarov round because I have a cz-82 and have carried it in my pocket and it works but is a tad bit too heavy , I think the p64 (radom) would probably be a good fit for a Mak round!
These are on sale at Buds Gun Shop right now. If I wasn't in the middle of an AR build with a kid on the way I might be looking at it. I don't have a pocket carry firearm and I'd like to get one at some point. Just not now.