Couldn't tell you. I first experienced it at age 17. Working on a barbed wire fence with my dad, lost the use of my hands to the point I couldn't hold a cup of hot coffee. Really wasn't much use at all that day. At age 19, was diagnosed with bilateral chondromalacia in the knees. That's a pre-arthritic condition. The USAF let me retrain from being an aircraft mechanic into still photography over it. I had bad knee pain from then until age 57 when shots of cockscomb extract suddenly ended my knee pain. I've had back pain since age 36. Been doing steroid injections alternating with nerve ablations for the past 5 years or so. Will be 69 in May. Last ablation was a couple months ago, lasted about 3 weeks. The injections usually last a bit longer. So do the ablations. I've been taking 150mg of oral Diclofenac sodium for a dozen years or so, and using the 1% gel topically a bit longer than that. Diclofenac has a long list of potentially bad side effects, but that stuff is black magic in a tube for the back & knee pain. Wife loves if her her back & knees, but doesn't tolerate it orally. I believe I'd be bed-ridden without it. And I'm still a young punk.
I get liver function panels regularly. And this is only half a joke: In my family, we depend on heart attacks to save us from the cancer. All four grandparents died from heart failure of one sort or another. Mom died of ovarian cancer, and dad had surgery to replace a valve in his heart. They were going to check a spot on his lung, and another on his tongue, but decided to pass on that. And an unsuspected dental infection ate the heart valve. He spent his last month alive in ICU with cascading systemic failures, but the heart is what finally did him in.
I smoked for a few months as a teenager, and had a 3-drink limit for my early adult life. Too many drunks and druggies in the family. Didn't want to be one of them. And I've never really LIKED the taste of alcohol. I'll occasionally have a drink with my wife while we watch a movie, and I take a sip of her drink once in a while. But we've got a gallon bottle of red wine here somewhere that has been in the house for several months, and not even been opened yet. Sometimes, a cold beer sounds good. Particularly after doing yardwork. Grandpa loved a cold beer after yardwork, and I guess I get that from him. But it's been a couple of years since the last six-pack I bought for my own or my wife's use. Mostly I have better things to spend my money one. Machine tools. Firearms. Gunpowder & primers... 
