I'm a big 22-250 fan myself. 40 grain Hornady vmax on coons or possums is my experience so far, and they are devastating. Gotta get out there on the pdogs.
I went with a 26" bbl on mine with a 1/12 twist and so far it seems as if the 50gr vmax bullets are deadly accurate out to 400 yards so them pdogs dont have a chance when I get out with it.